Ever since Abraham (Kris Kristofferson) was taken away by vampires, Daywalker Blade (Wesley Snipes) has not stopped looking for his father-like old partner, and finally rescued him in Eastern Europe. During Abraham's absence, Blade relied on his new partner Sgard for logistical support. Soon the vampire elders sent people to convey the armistice agreement, only because a new variant appeared among vampires - the reapers. The reapers feed on both humans and vampires, and their rapid metabolism leads to amazing needs. In order to protect mankind, Blade agreed to lead the vampire blood gang composed of Nessa (Leonor Varela), the daughter of the elders, and the snowman (Donnie Yen) to eliminate the reapers, but unexpectedly, all this was a conspiracy of vampires...