This drama is adapted from the Douban Reading serial novel "Six Sisters", written by Yi Bei. After the founding of New China, He Changsheng moved from Yangzhou Jiangdu to Huainan, Anhui with his family to support socialist construction, and took root by the Huai River. In the next twenty years, He Changsheng had six daughters in a row, but passed away in a car accident. The eldest sister He Jiali, grandmother He Wenshi, and mother Liu Meixin took on the burden of the family together and settled their sisters to start their own families. Times are changing, and the six sisters of the He family have also experienced ups and downs in marriage, work, and life, but they are united and face the ups and downs of life together. In the hardships of life, the six sisters finally understand the meaning of "home" that their father repeatedly emphasized during his lifetime.